DENARASE® High Salt
DENARASE® High Salt is a specialized variant of the traditional DENARASE® endonuclease, modified through selective amino acid substitutions to enhance its tolerance to high salt conditions. This engineered enzyme demonstrates superior resilience to increased salt levels and a wider pH range, offering augmented adaptability for bioprocessing tasks.
Specifically tailored from the wild-type Serratia marcescens endonuclease—a key tool in DNA removal for bioprocessing—DENARASE® High Salt retains the original enzyme's specificity for nucleic acids while exhibiting heightened performance across an extended range of salt concentrations and pH values, thereby providing increased operational flexibility in bioprocessing environments.
Remarkably, despite its modifications, DENARASE® High Salt maintains a high degree of similarity to the wild-type enzyme, allowing for its detection using standard Serratia marcescens endonuclease ELISA Kits, such as the DENARASE® ELISA Kit. The production of DENARASE® High Salt adheres to the proven, proprietary manufacturing processes of DENARASE®, utilizing a gram-positive Bacillus sp. strain. This production is executed under the ISO 9001 standard, eschewing the use of antibiotics, animal-derived raw materials, or materials with TSE/BSE risks, ensuring a high-quality and safe product for diverse bioprocessing applications. | 
