Overview of DENARASE®
Mechanism of Action
DENARASE® selectively cleaves the phosphodiester linkages within nucleotide sequences, generating smaller nucleic acid fragments approximately 3-5 base pairs in length. It exhibits activity across various nucleic acid configurations, including single-stranded, double-stranded, linear, circular, and supercoiled forms. Optimal performance is achieved when the enzyme is introduced prior to DNA release.
Manufacturing Insights
Developed for integration into commercial production workflows for biologics, DENARASE® adheres to the European Union's Good Manufacturing Practice (GMP) standards. Its innovative production methodology employs a gram-positive Bacillus species as the host organism, effectively reducing endotoxin contamination risks. The production process is distinguished by its exclusion of antibiotics, materials associated with transmissible spongiform encephalopathies (TSE/BSE), and animal-derived raw materials. | 
