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   About Us                      Animal Model         Research Application      Featured Products       Customized Service
 
Biohippo, in partnership with Shanghai Model Organisms, provides a comprehensive resource for translational studies with over 9,000 research-ready animal models and 19,000+ strains. We specialize in tailored solutions such as genetically modified models, phenotype analysis, and high-throughput screenings to advance life science research and drug development. Upholding the highest standards of animal welfare, reflected in our AAALAC accreditation, we ensure scientific integrity and reliability in all services.
 
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Animal Model

Research-ready Models

Research-ready Models

Customized Animal Models

Customized Animal Models

Breeding Service & Phenotypic Analysis

Breeding Service & Phenotypic Analysis

Our collection features a diverse range of meticulously developed models. Each animal model is developed with the utmost precision and care, ensuring high-quality, reliable resources for your research needs.
 
Humanized Animal Model à

Humanized Animal Models, encompassing both single-target and multi-target configurations, are engineered to precisely mimic human biological systems. These models are integral for researching complex diseases and evaluating novel therapies, particularly in immuno-oncology and infectious disease studies. Designed for flexibility, our models cater to various research needs, whether you require study-ready animals or customizable options for in-house humanization.
Immunodeficient Animal Model à

Immunodeficient Animal Models are pivotal in advancing research in immunology, oncology, and regenerative medicine. These models create an optimal environment for studying immune responses and disease progression. They play a crucial role in groundbreaking research areas like xenografting, stem cell studies, and pharmacodynamics.
Animal Disease Model à

Animal Disease Models represent a broad spectrum of human pathologies, are instrumental in elucidating disease mechanisms and advancing drug development. Leveraging the genetic and physiological similarities between mice and humans, our models are meticulously engineered to replicate specific human diseases.
Cre/Dre-Driver Mice à

Cre/Dre-Driver Mice utilize advanced Cre-lox technology for targeted genetic manipulation. These models feature 'floxed' sequences enabling precise gene activation or deletion. Key to our collection is inducible Cre systems like CreERT2, allowing controlled timing and location of gene expression. Ideal for creating a variety of genetic alterations, our Cre/Dre-Driver Mice are essential tools for in-depth genetic research and disease modeling.
Reporter Animal Modelà

Reporter Animal Models are vital tools for in vivo studies, including live cell imaging, cell lineage tracing, immunological research, and cancer studies. Our portfolio features a range of established models, including random reporter strains, Cre-based, and ROSA26 reporter strains. These models are equipped with knock-in or transgenic fluorescent reporter genes, facilitating detailed gene expression profiling, protein localization, and genetic lineage tracing.

Research Application

Explore our diverse animal models tailored to
advanced research areas.


Neuroscience Research
 
Mouse models are instrumental for investigating neural cell differentiation and aging, neural circuitry and synapses, glial cell functions, and nervous system pathologies.
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Cardiovascular Research
 
Genetically engineered mice are essential for studying cardiac development and vasculogenic, as well as for modeling the pathogenesis of cardiac diseases. 
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Immunology Research
 
We have established a list of mouse models in which distinct immune cell types have been labeled using luciferase and EGFP, enabling simple and highly sensitive in vivo studies.
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Metabolic Research
 
Our versatile platforms offer both genetically engineered and diet-induced diabetes models, ensuring our rodents are foundational to your diabetes research.
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Infectious Diseases
 
Genetically engineered inbred strains, humanized mice, and knockout models have advanced our understanding of infectious disease pathogenesis and facilitated preclinical assessments of vaccines and treatments for numerous human pathogens.
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Rare Diseases
 
Rare diseases, characterized by their low prevalence within the global population, are predominantly genetic in origin. Our portfolio of gene-engineered mouse models is pivotal for the exploration of novel therapies and the development of orphan drugs.
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Featured Animal Model

NMG(NOD.Cg-PrkdcscidIl2rgem1Smoc)
Catalog No.: NM-NSG-001
 
  • Highest degree of immunodeficiency
  • Long lifespan 
  • Excellent tumor xenograft model with minimal immune rejection, supporting traditional xenografts derived from cell lines, or PDX. 
  • Perfect recipient for human immune reconstitution, e.g., transiently humanized model via PBMC or engraftment of human CD34+ HSCs (hematopoietic stem cells)
Representative FACS data showing the drastic reduction of CD3+ T cells, CD19+ B cells and CD3-CD335+ NK cells in mouse splenocytes.
Human Immune System Reconstruction

C57BL/6JSmoc-Ccr8em1(hCCR8) Smoc
Catalog No.: NM-HU-190053
 
CCR8-humanized mouse model is a key resource for immunotherapy drug discovery, specifically targeting the CCR8/CCL1 signaling pathway implicated in cancer progression. This model is accurately engineered to express the human CCR8 gene, providing a reliable platform for studying tumor microenvironment dynamics and validating anti-CCR8 therapeutic efficacy. 
The Role of CCR8 in Cancer Progression
Anti-tumor efficacy validation of anti-CCR8 antibody in CCR8-humanized mice.
FACS analysis of binding of anti-hCCR8 antibody to T cells in spleens of CCR8-humanized mice.

Customized Animal Model Generation Service

We guarantee precise, customized models with verified genetics, tailored to your specific research needs.

Custom Animal Model Generation Service offers state-of-the-art solutions for advanced genetic research. Our services include gene knock-out (KO), gene knock-in (KI), point mutation introduction, targeted expression, random transgenes, etc. Tailored to meet specific research requirements, our services enable rapid development of robust and reliable animal models for a wide spectrum of biomedical research.
Gene KO offers customized gene knockout mouse models, designed to provide in-depth insights into genetic mechanisms and disease pathology. Utilizing advanced CRISPR/Cas9 technology, we create both conventional and conditional knockouts, enabling researchers to explore gene functions and streamline drug candidate evaluation with precision and reliability.

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Animal Model Generation Service Process



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     Please contact us at orders@biohippo.com or +1-866-986-9598